Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
نویسندگان
چکیده
BACKGROUND The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology. METHODS DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods. RESULTS We found no association between alcohol dependence and MAOA gene polymorphism. CONCLUSIONS Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.
منابع مشابه
Correction: Samochowiec, A., et al. Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology. Int. J. Environ. Res. Public Health 2015, 12, 3317–3326
1 Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland; E-Mails: [email protected] (A.S.); [email protected] (M.C.) 2 University Center for Education, University of Szczecin, Szwoleżerów 18a, 71-062 Szczecin, Poland; E-Mail: [email protected] 3 Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczec...
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